Overactive Thyroid Gland Hyperthyroidism

What is hyperthyroidism?

Neck cross-section showing the thyroid gland

Thyroxine is a body chemical (hormone) made by your thyroid gland. It is carried around your body in your bloodstream. It helps to keep your body's functions (your metabolism) working at the correct pace. Many cells and tissues in your body need thyroxine to keep them going correctly.

Hyperthyroidism means an overactive thyroid gland. When your thyroid gland is overactive it makes too much thyroxine. The extra thyroxine causes many of your body's functions to speed up. In contrast, if you have hypothyroidism, you make too little thyroxine; this causes many of the body's functions to slow down. See the separate leaflet called Underactive Thyroid Gland (Hypothyroidism) for more information.

Thyrotoxicosis is a term that may be used by doctors instead of hyperthyroidism. The two terms mean much the same.

What are the symptoms of hyperthyroidism?

The following are symptoms of having an overactive thyroid gland (hyperthyroidism):

• Being restless, nervous, emotional, irritable, sleeping poorly and 'always on the go'.
• Tremor of your hands.
• Losing weight despite an increased appetite.
• The sensation of having a 'thumping heart' (palpitations).
• Sweating, a dislike of heat and an increased thirst.
• Runny stools (diarrhoea) or needing to go to the toilet to pass stools more often than normal.
• Shortness of breath.
• Skin problems such as hair thinning and itch.
• Menstrual changes - your periods may become very light or infrequent.
• Tiredness and muscle weakness may be a feature.
• A swelling of your thyroid gland (a goitre) in the neck may occur.
• Eye problems if you have Graves' disease - see below under 'What are the causes of hyperthyroidism?'.

Most people with hyperthyroidism do not have all the symptoms but a combination of two or more is common. Symptoms usually develop slowly over several weeks. All the symptoms can be caused by other problems and so the diagnosis may not be obvious at first. Symptoms may be mild to start with but become worse as the level of thyroxine in your blood gradually rises.

Possible complications

If you have untreated hyperthyroidism:

• You have an increased risk of developing heart problems such as abnormal heart rhythm (atrial fibrillation), a weak heart (cardiomyopathy), angina and heart failure.
• If you are pregnant, you have an increased risk of developing some pregnancy complications.
• You have an increased risk of developing fragile bones (osteoporosis).

With treatment, the outlook (prognosis) is excellent as most of the symptoms and risks of complications go.

Who develops hyperthyroidism?

About 2 in 100 women and 2 in 1,000 men in the UK develop an overactive thyroid gland (hyperthyroidism) at some stage of their lives. It can occur at any age but it is more common as you become older.

What are the causes of hyperthyroidism?

There are various causes of having an overactive thyroid gland (hyperthyroidism). They include the following:

Graves' disease

This is the most common cause. It can occur at any age but is most common in women aged 20-50 years. It can affect anyone but there is often a family history of the condition. There may also be family members with other autoimmune diseases (for example, diabetes, rheumatoid arthritis and myasthenia gravis).

Graves' disease is also an autoimmune disease. The immune system normally makes tiny proteins (antibodies) which travel in your bloodstream to attack bacteria, viruses and other germs. In autoimmune diseases, the immune system makes antibodies against tissues of your body. If you have Graves' disease, you make antibodies that attach to your thyroid gland. These stimulate your thyroid gland to make lots of thyroxine. It is thought that something triggers your immune system to make these antibodies. The trigger is not known.

In Graves' disease the thyroid gland usually enlarges, which causes a swelling (goitre) in the neck. See the separate leaflet called Goitre (Thyroid Swelling). The eyes are also affected in about half of cases. If they are affected, your eyes are pushed forwards and look more prominent (proptosis). This can cause discomfort and watering of your eyes. Problems with eye muscles may also occur and lead to double vision. It is not clear why eye symptoms occur in some people who have Graves' disease. They may be due to the antibodies affecting the tissues around the eye. See the separate leaflet called Thyroid Eye Disease for more details.

Thyroid nodules

This is a less common cause of hyperthyroidism. Thyroid nodules are lumps which can develop in your thyroid gland. It is not clear why they develop. They are usually non-cancerous (benign) but contain abnormal thyroid tissue.

The abnormal thyroid tissue in your thyroid nodules does not respond to the normal controlling system which ensures that you make just the right amount of thyroxine. Therefore, if you have a thyroid nodule, you may make too much thyroxine.

• Sometimes only one nodule forms. This is called a toxic solitary adenoma. This most commonly occurs in people aged between 30 and 50 years.
• The thyroid may become generally lumpy or nodular. This most commonly occurs in older people and is called a toxic multinodular goitre.

Other causes

There are several other rare causes of hyperthyroidism. For example, some people who take the medicines amiodarone and lithium develop hyperthyroidism. There are various other rare conditions which result in excess thyroxine being made.

How is hyperthyroidism diagnosed?

A blood test can diagnose having an overactive thyroid gland (hyperthyroidism). A normal blood test will also rule it out if symptoms suggest that it may be a possible diagnosis. One or both of the following may be measured in a blood sample:

• Thyroid-stimulating hormone (TSH). This chemical (hormone) is made in the pituitary gland in the brain. It is released into the bloodstream. It stimulates the thyroid gland to make thyroxine. If the level of thyroxine in the blood is high then the pituitary gland releases less TSH. Therefore, a low level of TSH means that your thyroid gland is overactive and is making too much thyroxine.
• Thyroxine (T4). A high level of T4 confirms hyperthyroidism.

Sometimes the results of the tests are borderline. For example, a normal T4 but with a low TSH. Other tests are sometimes done to clarify the situation and the cause. For example, another blood test that measures T3 is sometimes helpful and an ultrasound scan of the thyroid gland or a thyroid scan may be done if you have a nodular goitre.

Also, if tests are borderline, one option is to repeat the tests a few weeks later, as sometimes borderline tests are due to another illness. Other tests may be done if a rare cause of hyperthyroidism is suspected.

In people with Graves' disease a blood test may detect specific autoantibodies which are commonly raised. However, these can also be raised in some people without Graves' disease so this is not a specific test for Graves' disease.

See the separate leaflet called Thyroid Function Tests for more information.

What are the treatments for hyperthyroidism?

The main aim of treatment of an overactive thyroid gland (hyperthyroidism) is to reduce your level of thyroxine to normal. Other problems, such as a large thyroid swelling (goitre) or associated eye problems, may also need treatment. Factors such as the underlying cause of the problem, your age and the size of any goitre are taken into account to decide on the best treatment plan.

Treatment options include the following:

Medicines - usually carbimazole

Antithyroid medicines can reduce the amount of thyroxine made by the overactive thyroid gland. The most common medicine used in the UK is carbimazole. Carbimazole does not affect the thyroxine which is already made and stored but reduces further production. Therefore, it may take 4-8 weeks of treatment for your thyroxine level to come down to normal. The dose of carbimazole needed to keep the thyroxine level normal varies from person to person. A high dose is usually given initially which is then reduced as your thyroxine levels come down.

Carbimazole is usually taken for 12-18 months at first. After this, in about half of cases, the condition will have settled down and the carbimazole can be stopped. If the condition flares up again some time in the future, a further course may be needed. However, in these cases an alternative treatment (for example, radioactive iodine) is often recommended. In about half of cases, carbimazole needs to be continued long-term to control symptoms. A different treatment may then be a better option if you do not want to take carbimazole long-term.

An alternative medication called propylthiouracil is usually given instead of carbimazole if you are pregnant. Carbimazole is safe to take if you are breastfeeding.

Radio-iodine

This involves taking a drink, or swallowing a capsule, which contains radioactive iodine. The main use of iodine in your body is to make thyroxine. Therefore, the radioactive iodine builds up in your thyroid gland. As the radioactivity is concentrated in your thyroid gland, it destroys some thyroid tissue which reduces the amount of thyroxine that you make. The dose of radioactivity to the rest of your body is very low and is not dangerous. However, it is not suitable if you are pregnant or breastfeeding. In addition, after treatment, women should not become pregnant for at least six months and men are advised not to father children for at least four months.

Following radio-iodine treatment, you should avoid prolonged contact with others for a specified time. This may be for 2-4 weeks, depending on the amount of radio-iodine you receive. The aim is to limit the exposure of radioactivity to others. For the specified period you will be advised to take precautions such as:

• Limit close contact with babies, children or pregnant women. Close contact means being within one metre; so, for example, don't cuddle children or allow them to sit on your lap.
• You may wish to apply similar precautions as above for contact with your pets.
• If you have children, or have a job where you have contact with children, you should discuss this with the specialist before treatment.
• Stay more than an arm's length away from other people.
• Sleep alone.
• Avoid going to places like cinemas, theatres, pubs and restaurants where you may be in close contact with other people.
• Take some time off work if your work involves close contact with other people.

Your specialist will give more detailed advice regarding these precautions.

Surgery

This involves removing part of your thyroid gland. It may be a good option if you have a large goitre which is causing problems in your neck. If too much thyroid tissue is removed then you will be given thyroxine tablets to keep your thyroxine level normal. It is usually a safe operation. However, as with all operations, there is a very small risk of complications.

Thyroid replacement therapy

It can be difficult for a doctor to judge just the right dose of carbimazole, or just the right amount of radio-iodine, to give in each case. Too much treatment may make your thyroxine level go too low. Not enough treatment means your level remains higher than normal. Regular blood tests are needed to check on the thyroxine level.

One option is to take a high dose of carbimazole each day deliberately, or to receive a one-off high dose of radio-iodine. This stops your thyroid gland making any thyroxine. You will then need to take a daily dose of thyroxine tablets to keep your blood level of thyroxine normal. This over-treatment and then taking replacement thyroxine is called 'block and replace'.

Treatment for eye problems

You may need to see an eye specialist if you develop the eye problems of Graves' disease. Relatively minor symptoms affect the eyes in about half of people with Graves' disease. Measures such as artificial tears, sunglasses and eye protectors whilst you sleep may be sufficient to help.

However, about 1 in 20 people with Graves' disease have severe eye changes. Treatment can then be more difficult and may include surgery, radiation treatment or steroid tablets.

If you smoke then it is important that you try to stop. Smoking can actually make your eye problems worse.

Beta-blocker medicines

Some people are given a beta-blocker medicine (for example, propranolol, atenolol) for a few weeks whilst the level of thyroxine is reduced gradually by one of the above treatments. Beta-blockers can help to reduce symptoms of tremor, the sensation of having a 'thumping heart' (palpitations), sweating, agitation and anxiety.

Follow-up

Regular checks are recommended, even after you finish a successful treatment for an overactive thyroid gland (hyperthyroidism). It is very important to have a regular blood test (at least every year) to check that you have the right level of thyroid hormone (thyroxine) in your blood. Your GP may do this test. This is because some people become hyperthyroid again at some time in the future. Others who have been treated successfully develop an underactive thyroid gland (hypothyroidism) in the future. If this occurs, it can usually be treated easily with thyroxine tablets.